This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this ...

Complex traits are influenced by genes and the environment, but especially the latter is difficult to pin down. This important study uses C. elegans to demonstrate that non-genetic differences in gene ...

This manuscript introduces a useful protein-stability-based fitness model for simulating protein evolution and unifying non-neutral models of molecular evolution with phylogenetic models. The model is ...

Time-lapse analyses of millions of antibiotic-stressed Escherichia coli characterize the diverse single-cell dynamics of persister cells that depend on antibiotics, culture conditions, and ...

Life has been announced as a winner in the first Crossref Metadata Awards, recognising its commitment to high-quality ...

Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.

Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.

Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...